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4A molecular sieves, with uniform 4A pore structure and high adsorption capacity, are vital in adsorption, separation, and catalysis. Sodium content, a critical parameter in their synthesis, significantly impacts performance. Sodium ions (Na+) in the framework influence pore size, charge balance, and ion exchange properties. Excessive Na+ reduces adsorption efficiency, while controlled levels optimize selectivity and stability. To address this, ion exchange processes (e.g., replacing Na+ with K+ or Ca2+) enhance performance for applications like water softening or air drying. In industrial settings, 4A molecular sieves with tailored Na+ content are integrated into packing and tower internals, ensuring efficient separation in chemical, petrochemical, and environmental industries. Controlling sodium content is key to achieving desired adsorption and mechanical properties, making it a focus in 4A molecular sieve production and application.