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4A molecular sieve, a widely used desiccant, relies on a unique drying principle for efficient moisture removal. Its structure features a uniform 0.4A pore size, enabling precise molecular sieving. This means only molecules smaller than 0.4A, like water vapor, can enter the pores, while larger molecules (e.g., nitrogen, oxygen) are excluded. The drying process is primarily physical adsorption, driven by van der Waals forces between water molecules and the sieve's silicoaluminophosphate framework. When saturated with moisture, the sieve can be regenerated by heating to 200-300°C, releasing adsorbed water and restoring its drying capacity. In industrial settings, 4A molecular sieve is often used as packing in drying towers, with tower internals like grid plates or packed beds optimizing contact between gas/liquid streams and the sieve. Its high adsorption selectivity and stability make it ideal for applications such as air drying, natural gas dehydration, and pharmaceutical solvent purification. Understanding this principle ensures efficient design and operation of drying systems, maximizing moisture removal efficiency.